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Table II Demographic and clinical data of the anti-HBe positive patients.

From: Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers

    

Nucleotides at positions

No. of substitutionsa

Genotype

Patient

Age/Sex

Clinical status

1762-1764

1858

1896

CPMs

UPMs

A

A1

55/M

Cirrhosis

AGG

C

G

0

0

 

A2

41/F

Cirrhosis

AGG

C

G

0

0

 

A3

45/M

Cirrhosis, HCC

AGG

C

G

0

1

 

A4

40/F

Cirrhosis

AGG

C

G

0

0

 

A5

10/F

Asymptomatic

TGA (mutant)

C

G

1

6

 

A6

52/M

CAH

TGA (mutant)

C

G

1

8

 

A7

38/M

CAH

AGG

C

G

0

2

 

A8

54/M

Cirrhosis

AGG

C

G

0

0

 

A9

52/M

CAH

AGG

C

G

0

4

 

A10

39/M

Asymptomatic

AGG

C

G

0

0

D

D1

36/M

CAH

AGG

T

G

0

2

 

D2

54/F

Asymptomatic

TGA (mutant)

T

A (stop)

2

7

 

D3

56/F

CAH

TGA (mutant)

T

A (stop)

2

13

 

D4

35/M

Cirrhosis

TGA (mutant)

T

A (stop)

2

5

 

D5

55/M

CAH

TGA (mutant)

T

A (stop)

2

8

 

D6

47/M

Asymptomatic

AGG

T

G

0

6

 

D7

53/M

Asymptomatic

AGG

T

G

0

6

F

F1

10/M

Asymptomatic

AGG

C

G

0

7

 

F2

35/M

CAH

AGG

T

A (stop)

1

8

  1. aNumber of common (CPMs) and uncommon (UPMs) point mutations (see text) in a 200-bp genome segment, from nt 1720 to nt 1919